Journal article
Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging
SV Liubinas, KJ Drummond, PM Desmond, A Bjorksten, AP Morokoff, AH Kaye, TJ O'Brien, BA Moffat
NMR in Biomedicine | WILEY | Published : 2014
DOI: 10.1002/nbm.3095
Abstract
This study aimed to evaluate and validate chemical shift imaging (CSI) for in vivo glutamate (Glu) quantification in patients with supratentorial gliomas. If validated, CSI could become an extremely useful tool to investigate metabolic dysfunction of Glu in excitotoxic neuropathologies. Quantitative CSI estimates of Glu concentrations were compared with known concentrations of Glu in aqueous phantom solutions. Forty-one patients with known or likely supratentorial gliomas underwent preoperative CSI. The spectra obtained were analyzed for Glu concentrations and Glu to creatine (Cr) ratios. These in vivo measurements were correlated against ex vivo Glu content quantified by high performance li..
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Grants
Awarded by National Health and Medical Research Council (NHMRC), Australia
Awarded by Cancer Australia
Funding Acknowledgements
This research was generously funded by the National Health and Medical Research Council (NHMRC), Australia (grant number 628301, 56992); The University of Melbourne, Australia; The Royal Australasian College of Surgeons; and Cancer Australia (509322).